Per Diem Nursing Jobs in Greenville, South Carolina
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Working as a nurse in Greenville
Greenville anchors South Carolina’s fast-growing Upstate, and its healthcare community keeps steady demand for nurses and CNAs who want flexible, per diem work. From acute care hospitals downtown to skilled nursing and senior-living facilities across Greer, Mauldin, Simpsonville, and Travelers Rest, Greenville offers a broad mix of settings for RNs, LPNs, and CNAs.
Major systems like Prisma Health — the largest health system in South Carolina — and Bon Secours St. Francis Health System care for patients across the Upstate, while a growing network of skilled nursing, rehabilitation, and assisted living communities keeps per diem opportunities open throughout the week.
South Carolina is a Nurse Licensure Compact (NLC) state. If you hold a qualifying multistate RN or LPN license from another compact state, you can practice in South Carolina without applying for a separate South Carolina license. CNAs must meet South Carolina certification requirements.
With Switch, you browse available shifts, choose when you work, and get paid quickly — giving you more control over your schedule and your income.
About Greenville
Greenville has become one of the Southeast’s most talked-about small cities, known for its walkable downtown, Falls Park on the Reedy, and a booming Upstate economy. With a growing population and a strong healthcare sector, Greenville is a popular market for nurses searching for per diem nursing jobs, RN jobs, LPN jobs, and CNA jobs with flexible scheduling.
Nursing pay in Greenville, South Carolina
RNs in the Greenville area typically earn $38–$46/hr, LPNs $28–$35, and CNAs $17–$18 (U.S. Bureau of Labor Statistics, May 2025).
Figures show typical area wages for staff roles (U.S. Bureau of Labor Statistics, May 2025) and vary by facility, shift, and experience. Per diem shifts on Switch often pay above these averages — you’ll see the exact rate on every shift before you claim it.
What nurses say about Switch
“Working for Switch has been a wonderful experience and has also been empowering for a busy mom like myself. I have the privilege to pick and choose my own schedule and work around my hectic schedule outside of work as a parent.”
“I have been with Switch for about five years now and the thing that I like the best about them is because they care about their workers. They pay me quickly, which is a good thing. Being with Switch brings me peace of mind. Great agency to work for!”
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FAQs about working in Greenville
Does Switch have shifts across Greenville?
Yes. Switch connects clinicians with opportunities throughout the Greenville area, including Greer, Mauldin, Simpsonville, Travelers Rest, and nearby Upstate communities as facilities become available.
Do I need a South Carolina nursing license to work per diem shifts in Greenville?
South Carolina is part of the Nurse Licensure Compact (NLC). If you hold a qualifying multistate RN or LPN license from another compact state, you can generally work in South Carolina without a separate South Carolina license. CNAs must hold a valid South Carolina certification before accepting shifts.
How much do per diem nurses and CNAs make in Greenville?
Pay varies by role, experience, facility type, and demand. Weekend, holiday, and high-demand shifts often pay more. With Switch, you’ll always see the exact pay before you accept a shift.
Can I pick up shifts around a full-time job or nursing school?
Yes. Many RNs, LPNs, and CNAs use Switch to add income around a full-time position, nursing school, or family life, with no minimum-hour requirements. You choose which shifts fit your schedule.