Per Diem Nursing Jobs in South Carolina
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Working as a nurse in South Carolina
South Carolina’s healthcare system stretches from the Upstate around Greenville and Spartanburg to the Midlands around Columbia and the Lowcountry around Charleston and Myrtle Beach, creating consistent demand for nurses and CNAs who want flexible schedules. From acute care hospitals to skilled nursing, rehabilitation, and senior living facilities, South Carolina offers a broad mix of settings for RNs, LPNs, and CNAs.
Major systems like Prisma Health — the largest in the state — MUSC Health, Roper St. Francis, Bon Secours, and Spartanburg Regional care for patients across South Carolina, while a wide network of post-acute and senior-care facilities keeps per diem demand steady.
South Carolina is a Nurse Licensure Compact (NLC) state. If you hold a qualifying multistate RN or LPN license from another compact state, you can practice in South Carolina without applying for a separate South Carolina license. CNAs must meet South Carolina certification requirements.
With Switch, you choose the shifts and facilities that fit your life and get paid quickly. Choose your city below to see local shifts and pay.
Nursing jobs by city in South Carolina
What nurses say about Switch
“Working for Switch has been a wonderful experience and has also been empowering for a busy mom like myself. I have the privilege to pick and choose my own schedule and work around my hectic schedule outside of work as a parent.”
“I have been with Switch for about five years now and the thing that I like the best about them is because they care about their workers. They pay me quickly, which is a good thing. Being with Switch brings me peace of mind. Great agency to work for!”
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You control your schedule. Browse available shifts in South Carolina and work when it works for you.
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FAQs about working in South Carolina
Which South Carolina cities does Switch cover?
Switch connects nurses and CNAs with per diem shifts across South Carolina, including Greenville, Spartanburg, Columbia, Charleston, and Myrtle Beach, with more markets added as demand grows. Choose your city to see local opportunities.
Do I need a South Carolina nursing license to work per diem shifts?
South Carolina is part of the Nurse Licensure Compact (NLC). If you hold a qualifying multistate RN or LPN license from another compact state, you can generally work in South Carolina without applying for a separate South Carolina license. CNAs must hold a valid South Carolina certification.
How much do per diem nurses and CNAs make in South Carolina?
Pay varies by role, experience, facility type, demand, and metro area. Weekend, holiday, and high-demand shifts often pay more. With Switch, you’ll always see the exact pay before you accept a shift — see your city page for local pay ranges.
Can I pick up shifts around a full-time job or nursing school?
Yes. Many RNs, LPNs, and CNAs use Switch to add income around a full-time position, nursing school, or family life, with no minimum-hour requirements. You choose which shifts fit your schedule.